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gambogenic acid, neo-gambogic acid, neogambogic acid

No.	Title	Href
1	Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin. Biol Pharm Bull. 2022;45(1):63-70. doi: 10.1248/bpb.b21-00511.	`Click`
2	Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth. Cell Death Dis. 2018 Feb 15;9(3):262. doi: 10.1038/s41419-018-0314-6.	`Click`
3	Synergistic effects of 5-fluorouracil and gambogenic acid on A549 cells: activation of cell death caused by apoptotic and necroptotic mechanisms via the ROS-mitochondria pathway. Biol Pharm Bull. 2014;37(8):1259-68. doi: 10.1248/bpb.b13-00972.	`Click`

No.

Title

Href

Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin. Biol Pharm Bull. 2022;45(1):63-70. doi: 10.1248/bpb.b21-00511.

Click

Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth. Cell Death Dis. 2018 Feb 15;9(3):262. doi: 10.1038/s41419-018-0314-6.

Click

Synergistic effects of 5-fluorouracil and gambogenic acid on A549 cells: activation of cell death caused by apoptotic and necroptotic mechanisms via the ROS-mitochondria pathway. Biol Pharm Bull. 2014;37(8):1259-68. doi: 10.1248/bpb.b13-00972.

Click

Name	Gambogenic acid
PubChem CID	10794070
Molecular Weight	630.8g/mol
Synonyms	gambogenic acid, neo-gambogic acid, neogambogic acid
Formula	C₃₈H₄₆O₈
SMILES	CC(=CCCC(=CCC1=C(C(=C2C(=C1O)C(=O)C3=CC4CC5C3(O2)C(C4=O)(OC5(C)C)CC=C(C)C(=O)O)CC=C(C)C)O)C)C
InChI	1S/C38H46O8/c1-20(2)10-9-11-22(5)13-15-25-30(39)26(14-12-21(3)4)33-29(31(25)40)32(41)27-18-24-19-28-36(7,8)46-37(34(24)42,38(27,28)45-33)17-16-23(6)35(43)44/h10,12-13,16,18,24,28,39-40H,9,11,14-15,17,19H2,1-8H3,(H,43,44)/b22-13+,23-16-/t24-,28+,37+,38-/m1/s1
InChIKey	RCWNBHCZYXWDOV-VSFMGBBVSA-N
ChEMBL ID	CHEMBL2205166
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	TengHuang
Use Part	Balsam
Habitat	India , Thailand , India
Flavor	Sour, Astringent
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Clusiaceae 　　　　　-->Genus: Garcinia 　　　　　　-->Species: Garcinia hanburyi

Pair Name	Gambogenic acid, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BECN1	hsa8678
	Up-regulation	Expression	MAP1LC3A	hsa84557
	Down-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Expression	SQSTM1	hsa8878
In Vitro Model	BEL-7402	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_5492
Result	Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin.

Pair Name	Gambogenic acid, Erlotinib
Partner Name	Erlotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	EGFR	hsa1956
	Down-regulation	Phosphorylation	FGFR3	hsa2261
	Down-regulation	Phosphorylation	FRS2	hsa10818
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Phosphorylation	RPS6	hsa6194
In Vitro Model	HCC827	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_2063
	HCC827 ER1	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_EJ07
	NCI-H1650	Minimally invasive lung adenocarcinoma	Homo sapiens (Human)	CVCL_1483
In Vivo Model	The human cell-derived tumor xenografts (CDX) were established by s.c. injecting 0.2 ml of the tumor cell suspension (1×10⁷ cells) mixed 1:1 with Matrigel (Becton Dickinson).
Result	Our findings provide preclinical evidence for using GNA as an FGFR signaling pathway inhibitor to overcome erlotinib resistance in NSCLC treatment or to enhance erlotinib efficacy when used as a combined administration.

Pair Name	Gambogenic acid, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Necroptosis
Gene Regulation	Up-regulation	Expression	AIFM1	hsa9131
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP9	hsa842
	Up-regulation	Expression	CYCS	hsa54205
	Up-regulation	Expression	PPID	hsa5481
	Up-regulation	Expression	RIPK1	hsa8737
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
Result	These mechanisms may be due to the toxicity of targeted toxin to mitochondria via the mitochondrial pathway.